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Article

Defining Interactions Between the Genome, Epigenome, and the Environment in Inflammatory Bowel Disease: Progress and Prospects.

Gastroenterology - 1 Jul 2023

Noble Alexandra J, Nowak Jan K, Adams Alex T, Uhlig Holm H, Satsangi Jack

Abstract excerpt

Recent advances in our understanding of the pathogenesis of inflammatory bowel disease (IBD) have highlighted the complex interplay between the genome, the epigenome, and the environment. Despite the exciting advances in genomics that have enabled the identification of over 200 susceptibility loci, these only account for a small proportion of the disease variance and the estimated heritability in IBD. It is...

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PMID: 37062395
DOI: 10.1053/j.gastro.2023.03.238

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