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Article

Challenges for epigenetic research in inflammatory bowel diseases.

Epigenomics - 1 Apr 2017

Kellermayer Richard

Abstract excerpt

The human epigenome may link environmental exposures and commensal microbiota changes to host pathology in respect to the developmental origins of inflammatory bowel diseases (ulcerative colitis [UC] and Crohn's disease [more appropriately Crohn disease, CD]). Genetic predisposition - prenatal, perinatal and pediatric environmental influences - microbiome aberration (dysbiosis) and immune dysregulation appear to...

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PMID: 28343422
DOI: 10.2217/epi-2016-0155

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