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Article

A thrombophilic allele of clotting Factor VII/VIIa promoting recurrent pulmonary emboli, clinical details, and a structural model of the altered protein: a case report.

Journal of medical case reports - 13 Apr 2023

Newman Kenneth, Daldal Fevzi, Dancis Andrew

Abstract excerpt

BACKGROUND: The clotting or hemostasis system is a meticulously regulated set of enzymatic reactions that occur in the blood and culminate in formation of a fibrin clot. The precisely calibrated signaling system that prevents or initiates clotting originates with the activated Factor Seven (FVIIa) complexed with tissue factor (TF) formed in the endothelium. Here we describe a rare inherited mutation in the FVII...

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Identifiers

PMID: 37055848
DOI: 10.1186/s13256-023-03833-0
PMCID: PMC10100170

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