Article
Effect of N-acetyl-l-cysteine on Cell Phenotype and Autophagy in Pichia pastoris Expressing Human Serum Albumin and Porcine Follicle-Stimulating Hormone Fusion Protein.
Molecules (Basel, Switzerland) - 29 Mar 2023
Xu Yingqing, Geng Zijian, Yang Chengxi, Zhou Hongwei, Wang Yixing, Kuerban Buayisham, Luo Gang
Abstract excerpt
Pichia pastoris is widely used for the production of recombinant proteins, but the low secretion efficiency hinders its wide application in biopharmaceuticals. Our previous study had shown that N-acetyl-l-cysteine (NAC) promotes human serum albumin and porcine follicle-stimulating hormone fusion protein (HSA-pFSHβ) secretion by increasing intracellular GSH levels, but the downstream impact mechanism is not clear....
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