The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity.

doi:10.3390/ijms21051858

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The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity.

International journal of molecular sciences - 9 Mar 2020

Cannata Attilio, De Luca Chiara, Korkina Liudmila G, Ferlazzo Nadia, Ientile Riccardo, Currò Monica, Andolina Giulia, Caccamo Daniela

Abstract excerpt

Systemic inflammation and immune activation are striking features of multiple chemical sensitivity (MCS). The rs2298383 SNP of ADORA2A gene, coding for adenosine receptor type 2A (A2AR), has been involved in aberrant immune activation. Here we aimed to assess the prevalence of this SNP in 279 MCS patients and 238 healthy subjects, and its influence on ADORA2A, IFNG and IL4 transcript amounts in peripheral blood...

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PMID: 32182774
DOI: 10.3390/ijms21051858
PMCID: PMC7084623

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