Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of the Cdk5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse model

9 May 2019

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor nerve cells in the brain and the spinal cord. Etiological mechanisms underlying the disease remain poorly understood; recent studies suggest that deregulation of p25/Cyclin-dependent kinase 5 (Cdk5) activity leads to the hyperphosphorylation of Tau and neurofilament (NF) proteins in ALS transgenic mouse model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31189016
DOI: 10.1093/hmg/ddz118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of the Cdk5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse modelPMID 31189016Read ↗

A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypesSemantic proximity Read ↗

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions.Semantic proximity Read ↗

TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg MiceSemantic proximity Read ↗

A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.Semantic proximity Read ↗

Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative DiseaseSemantic proximity Read ↗

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal DementiaSemantic proximity Read ↗

CDK5 activator protein p25 preferentially binds and activates GSK3βSemantic proximity Read ↗

TDP-43 pathology and functional deficits in wild-type and ALS/FTD mutant cyclin F mouse models.Semantic proximity Read ↗

AβPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576Semantic proximity Read ↗

Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.Semantic proximity Read ↗

CDK5: A Unique CDK and Its Multiple Roles in the Nervous SystemSemantic proximity Read ↗

Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.