Article
Concomitant TP53 mutation in early-stage resected EGFR-mutated non-small cell lung cancer: a narrative approach in a genetically admixed Brazilian cohort.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jan 2023
Machado-Rugolo J, Baldavira C M, Prieto T G, Olivieri E H R, Fabro A T, Rainho C A, Castelli E C, Ribolla P E M, Ab'Saber A M, Takagaki T, Nagai M A, Capelozzi V L
Abstract excerpt
TP53 mutations are frequent in non-small cell lung cancer (NSCLC) and have been associated with poor outcome. The prognostic and predictive relevance of EGFR/TP53 co-mutations in NSCLC is controversial. We analyzed lung tissue specimens from 70 patients with NSCLC using next-generation sequencing to determine EGFR and TP53 status and the association between these status with baseline patient and tumor...
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