Prognostic and predictive effects of TP53 co-mutation in patients with non-small cell lung cancer with rare treatable driver mutations.

doi:10.1016/j.lungcan.2025.108452

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Article

Prognostic and predictive effects of TP53 co-mutation in patients with non-small cell lung cancer with rare treatable driver mutations.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2025

Feng Jamie, Hueniken Katrina, Fan Zhen Jason, Zhan Luna Jia, Faour Elizabeth, Corke Lucy, Alghabban Abdulrahman, Leighl Natasha B, Liu Geoffrey, Bradbury Penelope A, Sacher Adrian, Eng Lawson, Stockley Tracy L, Tsao Ming Sound, Shepherd Frances A

Abstract excerpt

BACKGROUND: TP53 mutations (TP53-MUT) are common in NSCLC and have been reported as predictive of response and prognostic of poor outcome in EGFR-mutant NSCLC. The impact of TP53-MUT in NSCLCs with rarer driver mutations and approved targeted treatments is unclear. METHODS: Records of 436 patients were reviewed and associations between TP53 status, demographics, and outcomes (overall response [ORR], survival [OS]...

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Topics

Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Mutation

Prognosis

Middle Aged

Aged

Adult

Aged, 80 and over

Neoplasm Staging

Brain Neoplasms

Retrospective Studies

Source

Open in PubMed

Identifiers

PMID: 40373457
DOI: 10.1016/j.lungcan.2025.108452

Genes

TP53
EGFR

Provenance

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