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Article

Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation.

Molecular cell - 6 Apr 2023

Zou Zhongyu, He Chuan

Abstract excerpt

In this issue, Cieśla et al.1 report a translation regulation through ALKBH5-mediated 5'-UTR m6A demethylation of the SF3B1 transcript during leukemic transformation. The SF3B1 protein maintains efficient splicing and expression of transcripts encoding DNA damage repair components to restrain excessive DNA damage.

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Source

Identifiers

PMID: 37028412
DOI: 10.1016/j.molcel.2023.02.019

Genes

SF3B1
ALKBH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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