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Article

JAK2/STAT5 Pathway Mutation Frequencies in South African BCR/ABL Negative MPN Patients.

Hematology/oncology and stem cell therapy - 4 Apr 2023

Shires Karen L, Rust Adriana J, Harryparsad Rushil, Coburn Justin A, Gopie Ruth E

Abstract excerpt

BACKGROUND: Mutations in JAK2/STAT5 proliferation pathway genes are key in the diagnosis of myeloproliferative neoplasms (MPNBCR/ABLneg), with JAK2V617F being found in 50-97% of MPNBCR/ABLneg subtypes. Low JAK2V617F positivity at our facility suggested that our South African MPNBCR/ABLneg population may have a different mutational landscape. OBJECTIVES: We aimed to determine the JAK2/STAT5 mutation frequencies...

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Source

Identifiers

PMID: 37023224
DOI: 10.56875/2589-0646.1064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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