Article
Low JAK2 V617F Allele Burden in Ph-Negative Chronic Myeloproliferative Neoplasms Is Associated with Additional CALR or MPL Gene Mutations.
Genes - 12 Apr 2021
Makarik Tatiana V, Abdullaev Adhamjon O, Nikulina Elena E, Treglazova Svetlana A, Stepanova Elena E, Subortseva Irina N, Kovrigina Alla M, Melikyan Anait L, Kulikov Sergei M, Sudarikov Andrey B
Abstract excerpt
JAK2 (Janus kinase 2) V617F, CALR (Calreticulin) exon 9, and MPL (receptor for thrombopoietin) exon 10 mutations are associated with the vast majority of Ph-negative chronic myeloproliferative neoplasms (MPNs). These mutations affect sequential stages of proliferative signal transduction and therefore, after the emergence of one type of mutation, other types should not have any selective advantages for clonal...
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