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Article

Arsenic and an Old Place: Rescuing p53 Mutants in Cancer.

Cancer cell - 8 Feb 2021

Loh Stewart N

Abstract excerpt

Tumor suppressor p53 lacks conventional drug binding pockets that would facilitate rescue of cancer-driving mutations. In this issue, Chen et al. discover a new role for an old drug, arsenic trioxide, in binding and stabilizing p53. The arsenic atom binds in a conserved, cryptic site and reactivates multiple p53 mutants.

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Identifiers

PMID: 33561393
DOI: 10.1016/j.ccell.2021.01.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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