Article
Microbial variome database: point mutations, adaptive or not, in bacterial core genomes.
Molecular biology and evolution - 1 Jun 2013
Chattopadhyay Sujay, Taub Fred, Paul Sandip, Weissman Scott J, Sokurenko Evgeni V
Abstract excerpt
Analysis of genetic differences (gene presence/absence and nucleotide polymorphisms) among strains of a bacterial species is crucial to understanding molecular mechanisms of bacterial pathogenesis and selecting targets for novel antibacterial therapeutics. However, lack of genome-wide association studies on large and epidemiologically well-defined strain collections from the same species makes it difficult to...
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