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Article

A distant trophoblast-specific enhancer controls HLA-G expression at the maternal–fetal interface

13 Apr 2016

Abstract excerpt

HLA-G, a nonclassical HLA molecule uniquely expressed in the placenta, is a central component of fetus-induced immune tolerance during pregnancy. The tissue-specific expression of HLA-G, however, remains poorly understood. Here, systematic interrogation of the HLA-G locus using massively parallel reporter assay (MPRA) uncovered a previously unidentified cis-regulatory element 12 kb upstream of HLA-G with enhancer...

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PMID: 27078102
DOI: 10.1073/pnas.1602886113

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