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Article

Epigenomic machinery regulating pediatric AML: Clonal expansion mechanisms, therapies, and future perspectives.

Seminars in cancer biology - 1 Jul 2023

Chianese Ugo, Papulino Chiara, Megchelenbrink Wout, Tambaro Francesco Paolo, Ciardiello Fortunato, Benedetti Rosaria, Altucci Lucia

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and transcriptional etiology mainly presenting somatic and germline abnormalities. AML incidence rises with age but can also occur during childhood. Pediatric AML (pAML) accounts for 15-20% of all pediatric leukemias and differs considerably from adult AML. Next-generation sequencing technologies have enabled the research...

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PMID: 37003397
DOI: 10.1016/j.semcancer.2023.03.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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