Article
Droplet digital polymerase chain reaction improves the detection of BCR-ABL1 kinase domain mutation in Philadelphia chromosome-positive acute lymphoblastic leukemia.
International journal of laboratory hematology - 1 Aug 2023
Wan Li, Ma Jiao, Gong Xiaoyuan, Li Qinghua, Wang Ying, Wei Hui, Wang Jianxiang, Xiao Zhijian, Mi Yingchang
Abstract excerpt
INTRODUCTION: Sanger sequencing (SS) is the most frequently used method for detecting ABL1 kinase domain (KD) mutations in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). However, it cannot detect low levels of mutation. Recently, droplet digital polymerase chain reaction (ddPCR) has been developed as a sensitive technique for detecting mutations in hematological neoplasms....
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