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Article

Innovative rapid screening for complex BCR-ABL1 kinase domain mutations in TKI-treated leukaemia patients.

British journal of cancer - 1 Sept 2025

Lan Yanping, Deng Jun, He Pujing, Huang Wen, Zhu Anqi, Guo Xiaoxia, Xiong Lv, Huang Qiuying, Hu Yu, Li Qingge

Abstract excerpt

BACKGROUND: Screening for BCR-ABL1 kinase domain (KD) mutations is routinely implemented in cases of treatment failure for chronic myeloid leukaemia and Philadelphia-positive acute lymphoblastic leukaemia. However, timely deciphering their clonal relationship via mutation profiling that requires identification of mutation types, quantification of mutant abundance, and differentiation between compound and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40588514
DOI: 10.1038/s41416-025-03098-y
PMCID: PMC12405524

Genes

ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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