Article
An exponential increase in QTL detection with an increased sample size.
Genetics - 26 May 2023
Chitre Apurva S, Polesskaya Oksana, Munro Daniel, Cheng Riyan, Mohammadi Pejman, Holl Katie, Gao Jianjun, Bimschleger Hannah, Martinez Angel Garcia, George Anthony M, Gileta Alexander F, Han Wenyan, Horvath Aidan, Hughson Alesa, Ishiwari Keita, King Christopher P, Lamparelli Alexander, Versaggi Cassandra L, Martin Connor D, St Pierre Celine L, Tripi Jordan A, Richards Jerry B, Wang Tengfei, Chen Hao, Flagel Shelly B, Meyer Paul, Robinson Terry E, Solberg Woods Leah C, Palmer Abraham A
Abstract excerpt
Power analyses are often used to determine the number of animals required for a genome-wide association study (GWAS). These analyses are typically intended to estimate the sample size needed for at least 1 locus to exceed a genome-wide significance threshold. A related question that is less commonly considered is the number of significant loci that will be discovered with a given sample size. We used simulations...
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