Article
Understanding the role of the hematopoietic niche in Huntington's disease's phenotypic expression: in vivo evidence using a parabiosis model.
Neurobiology of disease - 1 May 2023
Rieux Marie, Alpaugh Melanie, Salem Shireen, Siddu Alberto, Saint-Pierre Martine, Denis Hélèna L, Rohweder Heike, Herrmann Frank, Bazenet Chantal, Lacroix Steve, Cicchetti Francesca
Abstract excerpt
In a previous study, we have shown that parabiotic coupling of a knock-in mouse model (zQ175) of Huntington's disease (HD) to wild-type (WT) littermates resulted in a worsening of the normal phenotype as seen by detection of mutant huntingtin protein (mHTT) aggregates within peripheral organs and the cerebral cortex as well as vascular abnormalities in WT mice. In contrast, parabiosis improved disease features in...
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