Article
Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.
Respiratory research - 23 May 2016
Chang Amy Y, Mann Tracy S, McFawn Peter K, Han Liang, Dong Xinzhong, Henry Peter J
Abstract excerpt
BACKGROUND: The hexapeptide SLIGRL-amide activates protease-activated receptor-2 (PAR-2) and mas-related G protein-coupled receptor C11 (MRGPRC11), both of which are known to be expressed on populations of sensory nerves. SLIGRL-amide has recently been reported to inhibit influenza A (IAV) infection in mice independently of PAR-2 activation, however the explicit roles of MRGPRC11 and sensory nerves in this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.