Article
Expression of gamma-aminobutyric acid receptors on neoplastic growth and prediction of prognosis in non-small cell lung cancer.
Journal of translational medicine - 24 Apr 2013
Zhang Xiaoxue, Zhang Rong, Zheng Yuanjie, Shen Jianfei, Xiao Dakai, Li Jin, Shi Xiaoshun, Huang Liyan, Tang Hailing, Liu Jun, He Jianxing, Zhang Haibo
Abstract excerpt
BACKGROUND: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the adult mammalian brain, but exerts physiologic effects other than that on neurotransmitter in non-neuronal peripheral tissues and organs. GABA may affect cancer growth through activation GABA receptors. We investigated the gene expression of GABA receptors in tissue of non-small cell lung cancers (NSCLC) and non-cancerous...
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