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Article

Landscape of chromatin remodeling gene alterations in endometrial carcinoma.

Gynecologic oncology - 1 May 2023

Momeni-Boroujeni Amir, Vanderbilt Chad, Yousefi Elham, Abu-Rustum Nadeem R, Aghajanian Carol, Soslow Robert A, Ellenson Lora H, Weigelt Britta, Murali Rajmohan

Abstract excerpt

OBJECTIVE: Chromatin remodeling genes (CRGs) encode components of epigenetic regulatory mechanisms and alterations in these genes have been identified in several tumor types, including gynecologic cancers. In this study, we sought to investigate the prevalence and clinicopathological associations of CRG alterations in endometrial carcinoma (EC). METHODS: We performed a retrospective analysis of 660 ECs sequenced...

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Identifiers

PMID: 36958196
DOI: 10.1016/j.ygyno.2023.03.010
PMCID: PMC10192087

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