Article

Fluorescence assay for simultaneous quantification of CFTR ion-channel function and plasma membrane proximity

2019-05-08

Abstract excerpt

CFTR, a plasma membrane anion channel, plays a key role in controlling transepithelial fluid movement. Excessive activation results in intestinal fluid loss during secretory diarrhoeas, while CFTR mutations underlie cystic fibrosis (CF). Anion permeability depends both on how well CFTR channels work (permeation/gating) and on how many are present at the membrane (reflecting folding, trafficking, metabolic stabili...

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Literature Corpus work: 839a9877-3c48-5fd1-af23-1bdcdc726b7d
DOI: 10.1101/631614

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