Article
Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.
Nature medicine - 1 Jun 2013
Grainger John R, Wohlfert Elizabeth A, Fuss Ivan J, Bouladoux Nicolas, Askenase Michael H, Legrand Fanny, Koo Lily Y, Brenchley Jason M, Fraser Iain D C, Belkaid Yasmine
Abstract excerpt
The commensal flora can promote both immunity to pathogens and mucosal inflammation. How commensal-driven inflammation is regulated in the context of infection remains poorly understood. Here, we show that during acute mucosal infection of mice with Toxoplasma gondii, inflammatory monocytes acquire a tissue-specific regulatory phenotype associated with production of the lipid mediator prostaglandin E2 (PGE2)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.