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Network-level analysis of ageing and its relationship with diseases and tissue regeneration in the mouse liver

21 Mar 2023

Abstract excerpt

The liver plays a vital role in maintaining whole-body metabolic homeostasis, compound detoxification and has the unique ability to regenerate itself post-injury. Ageing leads to functional impairment of the liver and predisposes the liver to non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). Mapping the molecular changes of the liver with ageing may help to understand the crosstalk of...

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PMID: 36944690
DOI: 10.1038/s41598-023-31315-2

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