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[Clonal hematopoiesis of undetermined potential (CHIP) and clonal cytopenia of unknown significance (CCUS) - Consequences for the clinic].

Deutsche medizinische Wochenschrift (1946) - 1 Apr 2023

Ziemann Frank, Metzeler Klaus Hans

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) refers to the outgrowth of blood cells from a hematopoietic stem cell (HSC) clone that acquired one or more somatic mutations, leading to a growth advantage compared to wild type HSCs. In the last years this age-associated phenomenon has been extensively studied, and several cohort studies found association between CH and age-related diseases, esp. leukaemia...

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PMID: 36990116
DOI: 10.1055/a-1873-4250

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