DNA methylation differences in monozygotic twins with Van der Woude syndrome

Abstract excerpt

Introduction Van der Woude syndrome (VWS) is an autosomal dominant disorder responsible for 2% of all syndromic orofacial clefts (OFCs), with IRF6 being the primary causal gene (70%). Cases may present with lip pits and either cleft lip, cleft lip with cleft palate, or cleft palate, with marked phenotypic discordance even among individuals carrying the same mutation. This suggests that genetic or epigenetic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cleft Lip and Palate Research
• Share to Craniofacial Disorders and Treatments
• Share to Folate and B Vitamins Research