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Article

Spectrum of BRCA1 interacting helicase 1 aberrations and potential prognostic and therapeutic implication: a pan cancer analysis.

Scientific reports - 17 Mar 2023

Long Guo, Hu Kuan, Zhang Xiaofang, Zhou Ledu, Li Juanni

Abstract excerpt

BRCA1 interacting helicase 1 (BRIP1) alteration was crucial in tumors and it was a potential therapeutic target in ovarian serous cystadenocarcinoma (OV). Although a small number of studies had focused on BRIP1, an extensive study of BRIP1 genetic mutation and its clinical application in different cancer types had not been analyzed. In the current study, we analyzed BRIP1 abnormal expression, methylation,...

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PMID: 36932143
DOI: 10.1038/s41598-023-31109-6
PMCID: PMC10023799

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