Article
Dps-dependent in vivo mutation enhances long-term host adaptation in Vibrio cholerae.
PLoS pathogens - 1 Mar 2023
Luo Mei, Chen Guozhong, Yi Chunrong, Xue Baoshuai, Yang Xiaoman, Ma Yao, Qin Zixin, Yan Jin, Liu Xiaoyun, Liu Zhi
Abstract excerpt
As one of the most successful pathogenic organisms, Vibrio cholerae (V. cholerae) has evolved sophisticated regulatory mechanisms to overcome host stress. During long-term colonization by V. cholerae in adult mice, many spontaneous nonmotile mutants (approximately 10% at the fifth day post-infection) were identified. These mutations occurred primarily in conserved regions of the flagellar regulator genes flrA,...
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