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Parkin, an E3 Ubiquitin Ligase, Plays an Essential Role in Mitochondrial Quality Control in Parkinson's Disease.

Cellular and molecular neurobiology - 1 Oct 2021

Wang Xiao-Le, Feng Si-Tong, Wang Zhen-Zhen, Yuan Yu-He, Chen Nai-Hong, Zhang Yi

Abstract excerpt

Parkinson's disease (PD), as one of the complex neurodegenerative disorders, affects millions of aged people. Although the precise pathogenesis remains mostly unknown, a significant number of studies have demonstrated that mitochondrial dysfunction acts as a major role in the pathogeny of PD. Both nuclear and mitochondrial DNA mutations can damage mitochondrial integrity. Especially, mutations in several genes...

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PMID: 32623547
DOI: 10.1007/s10571-020-00914-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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