The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.

doi:10.1186/s13059-023-02881-5

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Article

The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.

Genome biology - 13 Mar 2023

Goldswain Hannah, Dong Xiaofeng, Penrice-Randal Rebekah, Alruwaili Muhannad, Shawli Ghada T, Prince Tessa, Williamson Maia Kavanagh, Raghwani Jayna, Randle Nadine, Jones Benjamin, Donovan-Banfield I'ah, Salguero Francisco J, Tree Julia A, Hall Yper, Hartley Catherine, Erdmann Maximilian, Bazire James, Jearanaiwitayakul Tuksin, Semple Malcolm G, Openshaw Peter J M, Baillie J Kenneth, Emmett Stevan R, Digard Paul, Matthews David A, Turtle Lance, Darby Alistair C, Davidson Andrew D, Carroll Miles W, Hiscox Julian A

Abstract excerpt

BACKGROUND: The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein, associated with an increase in transmissibility. Genomes with D614G are accompanied by a P323L substitution in the viral polymerase (NSP12). However, P323L is not thought to...

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PMID: 36915185
DOI: 10.1186/s13059-023-02881-5
PMCID: PMC10009825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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