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Fragment length profiles of cancer mutations enhance detection of circulating tumor DNA in patients with early-stage hepatocellular carcinoma.

BMC cancer - 13 Mar 2023

Nguyen Van-Chu, Nguyen Trong Hieu, Phan Thanh Hai, Tran Thanh-Huong Thi, Pham Thu Thuy Thi, Ho Tan Dat, Nguyen Hue Hanh Thi, Duong Minh-Long, Nguyen Cao Minh, Nguyen Que-Tran Bui, Bach Hoai-Phuong Thi, Kim Van-Vu, Pham The-Anh, Nguyen Bao Toan, Nguyen Thanh Nhan Vo, Huynh Le Anh Khoa, Tran Vu Uyen, Tran Thuy Thi Thu, Nguyen Thanh Dang, Phu Dung Thai Bieu, Phan Boi Hoan Huu, Nguyen Quynh-Tho Thi, Truong Dinh-Kiet, Do Thanh-Thuy Thi, Nguyen Hoai-Nghia, Phan Minh-Duy, Giang Hoa, Tran Le Son

Abstract excerpt

BACKGROUND: Late detection of hepatocellular carcinoma (HCC) results in an overall 5-year survival rate of less than 16%. Liquid biopsy (LB) assays based on detecting circulating tumor DNA (ctDNA) might provide an opportunity to detect HCC early noninvasively. Increasing evidence indicates that ctDNA detection using mutation-based assays is significantly challenged by the abundance of white blood cell-derived...

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Identifiers

PMID: 36915069
DOI: 10.1186/s12885-023-10681-0
PMCID: PMC10009971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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