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Circulating DNA genome-wide fragmentation in early detection and disease monitoring of hepatocellular carcinoma

9 Apr 2024

Abstract excerpt

Genome-wide circulating cell-free DNA (ccfDNA) fragmentation for cancer detection has been rarely evaluated using blood samples collected before cancer diagnosis. To evaluate ccfDNA fragmentation for detecting early hepatocellular carcinoma (HCC), we first modeled and tested using hospitalized HCC patients and then evaluated in a population-based study. A total of 427 samples were analyzed, including 270 samples...

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PMID: 38680658
DOI: 10.1016/j.isci.2024.109701

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