Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The negative effect of G1958A polymorphism on MTHFD1 protein stability and HCC growth.

Cellular oncology (Dordrecht, Netherlands) - 1 Jun 2023

Rao Keqiang, Zheng Ke, Zhao Qin, He Jing, Zhou Bei, Hou Guofang, Sha Nannan, Wang Wang, Yan Man, Zhou Yue, Jin Yuting, Jiang Yuhui, Xia Qiang

Abstract excerpt

PURPOSE: Methylenetetrahydrofolate dehydrogenase (MTHFD1), a key enzyme on the folate pathway, has been implicated in the tumor development of distinct types of cancers. The single nucleotide polymorphism (SNP) of 1958G > A mutation in the coding region of MTHFD1 (arginine 653 is mutated into glutamine) has been detected in a significant proportion of clinical samples of hepatocellular carcinoma (HCC). METHODS :...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to MTHFD1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Liver Neoplasms

Share to Methylenetetrahydrofolate Dehydrogenase (NADP)

Share to Minor Histocompatibility Antigens

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 36913067
DOI: 10.1007/s13402-023-00780-2
PMCID: PMC12974683

Genes

MTHFD1
TRIM21

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The negative effect of G1958A polymorphism on MTHFD1 protein stability and HCC growth.PMID 36913067Read ↗

A Review of Small-Molecule Inhibitors of One-Carbon Enzymes: SHMT2 and MTHFD2 in the SpotlightSemantic proximity Read ↗

p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage.Semantic proximity Read ↗

More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?Semantic proximity Read ↗

MTHFD2 in healthy and cancer cells: Canonical and non-canonical functionsSemantic proximity Read ↗

Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolismSemantic proximity Read ↗

JMJD5 regulates metabolism by hydroxylating ISY1, and regulating the Arginine Methyltransferase PRMT6Semantic proximity Read ↗

The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1Semantic proximity Read ↗

Multifaceted role of serine hydroxymethyltransferase in health and diseaseSemantic proximity Read ↗

One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppressionSemantic proximity Read ↗

Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation.Semantic proximity Read ↗

Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).Semantic proximity Read ↗

Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma PrognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.