Cranial and extracranial large-vessel giant cell arteritis share a genetic pattern of interferon-gamma pathway.

doi:10.55563/clinexprheumatol/3cqh12

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Article

Cranial and extracranial large-vessel giant cell arteritis share a genetic pattern of interferon-gamma pathway.

Clinical and experimental rheumatology - 1 Apr 2023

Prieto-Peña Diana, Genre Fernanda, Pulito-Cueto Verónica, Ocejo-Vinyals Javier Gonzalo, Atienza-Mateo Belén, Muñoz Jiménez Alejandro, Ortiz-Sanjuán Francisco, Romero-Yuste Susana, Moriano Clara, Galindez-Agirregoikoa Eva, Calvo Itziar, Ortego Centeno Norberto, Álvarez-Rivas Noelia, Miranda-Filloy Jose A, Baldivieso-Achá Juan Pablo, Blanco Ricardo, Gualillo Oreste, Martín Javier, Castañeda Santos, López-Mejías Raquel, Remuzgo-Martínez Sara, González-Gay Miguel A

Abstract excerpt

OBJECTIVES: Two main different clinical phenotypes of giant cell arteritis (GCA) have been described, the classic cranial pattern and the extracranial large-vessel (LV) pattern. Since interferon gamma (IFNG) has shown to be a pivotal cytokine in the pathophysiology of GCA, our aim was to evaluate for the first time the influence of IFNG and IFNG receptor 1 (IFNGR1) polymorphisms in the different clinical...

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PMID: 36533991
DOI: 10.55563/clinexprheumatol/3cqh12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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