Article
Preimplantation Genetic Testing for Aneuploidy (PGT-A) Reveals High Levels of Chromosomal Errors in In Vivo-Derived Pig Embryos, with an Increased Incidence When Produced In Vitro.
Cells - 2 Mar 2023
Jochems Reina, Canedo-Ribeiro Carla, Silvestri Giuseppe, Derks Martijn F L, Hamland Hanne, Zak Louisa J, Knol Egbert F, Handyside Alan H, Grindflek Eli, Griffin Darren K
Abstract excerpt
Preimplantation genetic testing for aneuploidy (PGT-A) is widespread, but controversial, in humans and improves pregnancy and live birth rates in cattle. In pigs, it presents a possible solution to improve in vitro embryo production (IVP), however, the incidence and origin of chromosomal errors remains under-explored. To address this, we used single nucleotide polymorphism (SNP)-based PGT-A algorithms in 101 in...
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