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CRISPR-based screening identifies XPO7 as a positive regulator of senescence

10 Mar 2023

Abstract excerpt

Dear Editor, Cells enter senescence, or irreversible growth arrest, when exposed to stressors such as DNA damage, epigenetic alterations and chronic inflammation (Zhao and Chen, 2022). In aging and aging-related diseases, senescent cells are known to accumulate across tissues and organs (Sun et al., 2022; Lopez-Otin et al., 2023). Although stem cells to a certain extent are capable of repairing and regenerating...

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Share to Circadian rhythm and melatonin
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PMID: 36897256
DOI: 10.1093/procel/pwad012

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