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Ex vivopurging of cancer cells from ovarian tissue using photodynamic therapy: a novel strategy to restore fertility in leukemia patients

1 Jan 2023

Abstract excerpt

Abstract STUDY QUESTION Is it possible to purge leukemia cells from ovarian tissue (OT) fragments before transplantation? SUMMARY ANSWER Our photodynamic therapy (PDT) approach has been shown to efficiently destroy leukemia cells from tumor-infiltration mimicking models (TIMs), indicating the feasibility of this technique to purge OT samples. WHAT IS KNOWN ALREADY Autotransplantation of cryopreserved OT is the...

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PMID: 36895885
DOI: 10.1093/hropen/hoad005

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