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Patient-derived spheroids and patient-derived organoids simulate evolutions of lung cancer

18 Feb 2023

Abstract excerpt

Cancer cells harbor many genetic mutations and gene expression profiles different from normal cells. Patient-derived cancer cells (PDCC) are preferred materials in cancer study. We established patient-derived spheroids (PDSs) and patient-derived organoids (PDOs) from PDCCs isolated from the malignant pleural effusion in 8 patients. The morphologies suggested that PDSs may be a model of local cancer extensions,...

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PMID: 36895411
DOI: 10.1016/j.heliyon.2023.e13829

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