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Modeling Cell Communication in Cancer With Organoids: Making the Complex Simple

18 Mar 2020

Abstract excerpt

Homotypic and heterotypic interactions between cells are of crucial importance in multicellular organisms for the maintenance of physiological functions. Accordingly, changes in cell-to-cell communication contribute significantly to tumor development. Cancer cells engage the different components of the tumor microenvironment (TME) to support malignant proliferation, escape immune control, and favor metastatic...

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PMID: 32258040
DOI: 10.3389/fcell.2020.00166

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