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Organoids technology in cancer research: from basic applications to advanced ex vivo models

22 May 2025

Abstract excerpt

Patient-derived organoids (PDOs) are tridimensional cultures derived from the stem component of a tissue. They preserve the genetic and phenotypic characteristics of the tissue of origin, and represent valuable in vitro models for drug screening, biomarker discovery, cell therapy and genetic modification. Importantly, PDOs reproduce the tumor behavior and can predict therapeutic responses, making them relevant...

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PMID: 40476002
DOI: 10.3389/fcell.2025.1569337

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