Article
Discordant growth of nasal cartilage and bone contributes to phenotypic variability of the skull in a mouse model.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2023
Book Shae A, Moore Alyssa C, Tourigny Madeline S G, Barr Kevin, Willmore Katherine E
Abstract excerpt
BACKGROUND: We previously determined a nonlinear relationship between connexin 43 (Cx43) function and craniofacial phenotypic variation in the mutant mouse model G60S/+, and that this variation was driven by nasal bone deviation. While nonlinearities in the genotype-phenotype map appear to be common, few studies have looked at the developmental processes that underlie this nonlinearity. Here, we investigated the...
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