Connexin 43 contributes to phenotypic robustness of the mouse skull.

Abstract excerpt

BACKGROUND: We compared skull shape and variation among genetically modified mice that exhibit different levels of connexin43 (Cx43) channel function, to determine whether Cx43 contributes to craniofacial phenotypic robustness. Specifically, we used two heterozygous mutant mouse models (G60S/+ and I130T/+) that, when compared to their wildtype counterparts, have an ~80% and ~50% reduction in Cx43 function,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Connexin 43
• Share to Craniofacial Abnormalities