Article
Circulating MicroRNAs Identify Early Phenotypic Changes in Sarcomeric Hypertrophic Cardiomyopathy.
Circulation. Heart failure - 1 Jun 2023
Sucharov Carmen C, Neltner Bonnie, Pietra Ashley E, Karimpour-Fard Anis, Patel Joshen, Ho Carolyn Y, Miyamoto Shelley D
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. Pathogenic germline variation in genes encoding the sarcomere is the predominant cause of disease. However diagnostic features, including unexplained left ventricular hypertrophy, typically do not develop until late adolescence or after. The early stages of disease pathogenesis and the mechanisms underlying the transition to...
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