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Association of germline variants in telomere maintenance genes (POT1, TERF2IP, ACD, and TERT) with spitzoid morphology in familial melanoma: A multi-center case series

30 Jan 2023

Abstract excerpt

Background Spitzoid morphology in familial melanoma has been associated with germline variants in POT1 , a telomere maintenance gene (TMG), suggesting a link between telomere biology and spitzoid differentiation. Objective To assess if familial melanoma cases associated with germline variants in TMG ( POT1 , ACD , TERF2IP , and TERT ) commonly exhibit spitzoid morphology. Methods In this case series, melanomas...

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Share to Cutaneous Melanoma Detection and Management
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PMID: 36876055
DOI: 10.1016/j.jdin.2023.01.013

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