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Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3 ‐mediated mitophagy

5 Mar 2023

Abstract excerpt

Radiation resistance is the leading cause of radiotherapy failure in patients with cancer. Enhanced DNA damage repair is the main reason for cancer cells to develop resistance to radiation. Autophagy has been widely reported to be linked to increased genome stability and radiation resistance. Mitochondria are highly involved in the cell response to radiotherapy. However, the autophagy subtype mitophagy has not...

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PMID: 36871142
DOI: 10.1111/febs.16769

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