Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.

Molecular cancer therapeutics - 1 Sept 2015

Liu Rui, Fan Ming, Candas Demet, Qin Lili, Zhang Xiaodi, Eldridge Angela, Zou June X, Zhang Tieqiao, Juma Shuaib, Jin Cuihong, Li Robert F, Perks Julian, Sun Lun-Quan, Vaughan Andrew T M, Hai Chun-Xu, Gius David R, Li Jian Jian

Abstract excerpt

Tumor adaptive resistance to therapeutic radiation remains a barrier for further improvement of local cancer control. SIRT3, a member of the sirtuin family of NAD(+)-dependent protein deacetylases in mitochondria, promotes metabolic homeostasis through regulation of mitochondrial protein deacetylation and plays a key role in prevention of cell aging. Here, we demonstrate that SIRT3 expression is induced in an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to CDC2 Protein Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinases

Share to Mitochondrial Proteins

Share to NF-kappa B

Share to Radiation Tolerance

Share to Sirtuin 3

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 26141949
DOI: 10.1158/1535-7163.MCT-15-0017
PMCID: PMC4560959

Genes

SIRT3
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.PMID 26141949Read ↗

Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3 ‐mediated mitophagySemantic proximity Read ↗

The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in CancerSemantic proximity Read ↗

Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.Semantic proximity Read ↗

SIRT3: Oncogene and Tumor Suppressor in CancerSemantic proximity Read ↗

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during StressSemantic proximity Read ↗

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and CarcinogenesisSemantic proximity Read ↗

Human sirtuin 3 (SIRT3) deacetylates histone H3 lysine 56 to promote nonhomologous end joining repair.Semantic proximity Read ↗

Unraveling Mitochondrial Determinants of Tumor Response to Radiation TherapySemantic proximity Read ↗

SirT3 Regulates the Mitochondrial Unfolded Protein ResponseSemantic proximity Read ↗

Sirtuin‐3 (SIRT3), a novel potential therapeutic target for oral cancerSemantic proximity Read ↗

SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesisSemantic proximity Read ↗

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.