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Article

Niclosamide inhibits epithelial-mesenchymal transition with apoptosis induction in BRAF/ NRAS mutated metastatic melanoma cells.

Toxicology in vitro : an international journal published in association with BIBRA - 1 Jun 2023

Thatikonda Sowjanya, Pooladanda Venkatesh, Tokala Ramya, Nagula Shankaraiah, Godugu Chandraiah

Abstract excerpt

Malignant melanoma is considered a deadly aggressive form of skin cancer that frequently metastasizes to various distal organs, which harbors mutations of the BRAF or NRAS which occur in 30 to 50% of melanoma patients. The growth factors secreted by melanoma cells contribute to tumor angiogenesis with the acquisition of metastatic potential by epithelial-mesenchymal transition (EMT) and drive melanoma growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36870549
DOI: 10.1016/j.tiv.2023.105579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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