Article
Targeting miR-21 with Sophocarpine Inhibits Tumor Progression and Reverses Epithelial-Mesenchymal Transition in Head and Neck Cancer.
Molecular therapy : the journal of the American Society of Gene Therapy - 6 Sept 2017
Liu Wei, Zhang Beilei, Chen Guo, Wu Wenjiao, Zhou Lin, Shi Yaru, Zeng Qi, Li Yanqiu, Sun Youwei, Deng Xingming, Wang Fu
Abstract excerpt
A major challenge for cancer chemotherapy is the development of safe and clinically effective chemotherapeutic agents. With its low toxicity profile, sophocarpine (SC), a naturally occurring tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L, has shown promising therapeutic properties, including anti-inflammatory, anti-nociceptive, and antivirus activities. However, the antitumor efficacy of...
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