Article
Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice.
Scientific reports - 9 Nov 2015
Mao Jian-Hua, Langley Sasha A, Huang Yurong, Hang Michael, Bouchard Kristofer E, Celniker Susan E, Brown James B, Jansson Janet K, Karpen Gary H, Snijders Antoine M
Abstract excerpt
Evidence has emerged that suggests a link between motor deficits, obesity and many neurological disorders. However, the contributing genetic risk factors are poorly understood. Here we used the Collaborative Cross (CC), a large panel of newly inbred mice that captures 90% of the known variation among laboratory mice, to identify the genetic loci controlling rotarod performance and its relationship with body...
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